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Bonaca, MD, a cardiologist with the University of Colorado School of Medicine, noted that PAD is often the first manifestation of cardiovascular disease in patients with diabetes

Anyone starting semaglutide should be educated on the signs of pancreatitis, such as sudden, severe abdominal pain, and seek medical attention immediately if symptoms occur

However, human thyroid tissue has significantly fewer GLP-1 receptors on C-cells compared to rodent thyroid tissue, which likely explains why this risk has not materialized in human clinical data

The medications evaluated include widely used drugs such as Ozempic, Wegovy, and Mounjaro, which are prescribed to treat type 2 diabetes and are increasingly used for weight loss